Michael W. Pelter, Ph.D.
Associate Professor of Chemistry
Office: Gyte 281
|Ph.D.||Organic Chemistry, Miami University, Oxford, OH|
|M.S.||Chemistry, Shippensburg University of Pennsylvania, Shippensburg, PA|
|B.S.||Biology, Juniata College, Huntingdon, PA|
Most organic laboratory textbooks use a standard “cookbook” approach, where the students know everything about the product and results of the experiment before starting. In the investigative approach, students are given the experimental procedure and the structures of starting materials and reagents. They are provided with no information on the product. Thus, this approach mimics the situation they would find in a professional appointment in that they are provided with the tools and the knowledge to determine the identity of the product.
Fluorous-phase Palladium Catalysts:
Oxime palladacycle catalysts have shown unique chemoselectivity in Sonogashira reactions with di- and trihalobenzenes. Fluorous oxime palladacycle catalysts are currently being developed and their utility explored as catalysts with potentially improved stability, activity, and selectivity. The presence of the fluorous tag on the catalyst allows the reactions to be carried out in the solution phase while permitting an easy separation of the catalyst from the desired product. Additionally, this methodology allows for catalyst recovery and reuse. A three step synthesis of the catalysts in good yield from readily available starting materials has been developed and the stability and selectivity of fluorous oxime palladacycles as homogeneous catalysts for the Sonogashira cross-coupling reaction is being explored with several substrates. As part of this study, a comparison of conventional and microwave heating methods is under investigation for the coupling reactions.
In fall 2010, I developed and taught a senior-level course entitled “Molecular Modeling and Visualization.” While the course is designed to teach students the capabilities of the Gaussian09 software, I am finding that my own knowledge of molecular modeling is being taken to the next level. In July 2010, I attended a Gaussian, Inc. Workshop entitled “Introduction to Gaussian: Theory and Practice” at the Ohio Supercomputing Center in Columbus, OH. I am now to expanding my utilization of Gaussian09 from the classroom to the research environment.
In addition to computational studies on the oxime palladacycle catalysts discussed above, I am also collaborating with Dr. James Takacs, Bessey Professor and Chair of Chemistry at the University of Nebraska-Lincoln. The research group of Dr. Takacs is presently using chirality-directed metal complexation to define an exciting new strategy for preparing chiral self-assembled ligand (SAL) libraries. Using SALs to prepare heterobimetallic catalyst systems is an effective way to carry out catalytic asymmetric synthesis such as the palladium-catalyzed asymmetric allylic amination reactions. My contribution to the project is to perform computational studies on the heterobimetallic catalyst systems and their relative stability with different metals. The spectral properties will also be studied.
PUBLICATIONS AND PUBLISHED ABSTRACTS
M. W. Pelter*, L. S. W. Pelter*, K. Berry, A. Harrigan, M. Hugg, K. Johnson “Synthesis and activity of fluorous-phase oxime palladacycle catalysts” Abstracts of Papers, 241st American Chemical Society National Meeting, Anaheim, CA (March 2011)
M. W. Pelter*, L. S. W. Pelter*, K. Pawlus, A. Henderlong “Molecular Modeling in Sophomore Organic Chemistry: Implementation of a Guided-Inquiry Approach.” Abstracts of Papers, MWRM2009 – 44th Midwest Regional Meeting of the American Chemical Society, Iowa City, IA (October 2009)
M. W. Pelter*, L. S. W. Pelter*, A. E. Walsko, R. Longfellow “Synthesis and Activity of Fluorous-Phase Oxime Palladacycle Catalysts.” Abstracts of Papers, MWRM2009 – 44th Midwest Regional Meeting of the American Chemical Society, Iowa City, IA (October 2009)
L. S. W. Pelter,* A. Amico, N. Gordon, C. Martin, D. Sandifer, M. W. Pelter, “Analysis of Peppermint Leaf and Spearmint Leaf Extracts by Thin Layer Chromatography.” Journal of Chemical Education, 2008, 85, 133-134. DOI: 10.1021/ed085p133.
M. W. Pelter* and A. E. Walsko “Synthesis and Activity of Fluorous-Phase Oxime Palladacycle Catalysts.” Abstracts of Papers, CERMACS2007 – Central Regional Meeting of the American Chemical Society, Covington, KY (May 2007).
R. E. Verduzco, J. M. McDonald, M. W. Pelter, L. S. W. Pelter* “Selectivity and Reactivity of Sonogashira Coupling Reactions.” Abstracts of Papers, CERMACS2007 – Central Regional Meeting of the American Chemical Society, Covington, KY (May 2007).
M. W. Pelter, “Brewing Science: Using Beer and the Brewing Process to Stimulate Interest in Science and the Science Laboratory.” Journal of College Science Teaching, 2006, 35(5), 48-52.
M. W. Pelter, “Beer: Good for Cooking and Chemistry” Cooking with Chemistry Symposium, Abstracts of Papers, 19th Biennial Conference on Chemical Education, West Lafayette, IN (August 2006)
L. S. W. Pelter* and M. W. Pelter* “Microwave Heating in the Undergraduate Organic Laboratory.” Abstracts of Papers, 19th Biennial Conference on Chemical Education, West Lafayette, IN (August 2006)
M. W. Pelter, “Brewing Science: Using Beer to Stimulate Interest in Science.” Abstracts of Papers, 19th Biennial Conference on Chemical Education, West Lafayette, IN (August 2006)
M. W. Pelter* and J. McQuade. “Brewing Science in the Chemistry Laboratory: A ‘Mashing’ Investigation of Starch and Carbohydrates.” Journal of Chemical Education, 2005, 82, 1811. DOI: 10.1021/ed082p1811
M. W. Pelter, “Brewing science: Using beer to stimulate interest in science” Abstracts of Papers, 230th American Chemical Society National Meeting, Washington, DC, (August 2005).
L. S. W. Pelter*, B. Heiberger, S. E. Brown, M. Pelter, “Synthesis and coupling of halogenated benzene compounds useful in the construction of nanoelectronic components” Abstracts of Papers, 230th American Chemical Society National Meeting, Washington, DC, (August 2005).
M. W. Pelter,* L. S. W. Pelter,* D. Colovic, R. Strug “The Microscale Synthesis of 1-Bromo-3-chloro-5-iodobenzene: An Improved Deamination of 4-Bromo-2-Chloro-6-iodoaniline.” Journal of Chemical Education, 2004, 81, 111-112. DOI: 10.1021/ed081p111
R. J. Strug, K. R. Berg, A. S. Gorcowski, S. L. Snyder, S. E. Brown, L. Pelter*, M. Pelter,* “Combinatorial Approach to Organic Synthesis of Nanoelectronic Components” Abstracts of Papers, 18th National Conference On Undergraduate Research (NCUR 2004), Indianapolis, IN. (April 2004)
M. W. Pelter,* L. S. W. Pelter*, R. Strug, K. Berg, A. Gorkowski, “Combinatorial Screening of Reagents and Catalysts in Homogeneous Metal Mediated Cross-Coupling Reactions” Abstracts of Papers, 38th National Organic Symposium, Bloomington, IN. (June 2003).
M. W. Pelter,* L. S. W. Pelter, D. Colovic, R. Strug, “Linking Strategies for Solid Phase Synthesis: Polymer Supported Synthesis of Conjugated Oligomers” Council on Undergraduate Research Undergraduate Research Posters on the Hill, Washington, DC. (April 2002)
M. W. Pelter,* L. S. W. Pelter, J. M. Tour, D. Colovic, V. Eulloqui, “Polymer Supported Synthesis of Conjugated Oligomers: Linking Strategies for Solid Phase Synthesis” Abstracts of Papers, 36th Midwest Regional Meeting of the American Chemical Society, Lincoln, NE (October 2001)
M. W. Pelter*, R. M. Macudzinski, and M. E. Passarelli “A Microscale Oxidation Puzzle.” Journal of Chemical Education, 2000, 77, 1481. DOI: 10.1021/ed077p1481
AREAS OF INSTRUCTION